Title:
【発明の名称】モノクローナル抗体抗―Her2により誘導されるアポトーシス
Document Type and Number:
Japanese Patent JP2002502230
Kind Code:
A
Abstract:
The present invention relates to an antibody or fragment thereof which recognizes an epitope on a Her2 polypeptide that is recognized by the monoclonal antibody produced by the hybridoma cell line ATCC No. HB-12078. The invention further relates to a hybridoma cell line capable of producing such an antibody. Also, the invention pertains to an in vitro method for inducing apoptosis in Her2 expressing cells comprising administering the inventive antibody. Finally, the present invention discloses uses of such an antibody and pharmaceutical compositions comprising the antibody according to the present invention.
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Inventors:
Arakawa, Tutom
Kita, Yoshiko A
Kita, Yoshiko A
Application Number:
JP52138697A
Publication Date:
January 22, 2002
Filing Date:
December 04, 1996
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C12N15/02; A61K39/395; A61P35/00; A61P43/00; C07K14/82; C07K16/32; C07K16/46; C12N5/10; C12N5/20; C12P21/08; A61K38/00; C12R1/91; A61K39/00; (IPC1-7): C12N15/02; A61K39/395; A61P35/00; A61P43/00; C07K16/32; C07K16/46; C12N5/10; C12P21/08
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)