Title:
抗IGF-I受容体抗体
Document Type and Number:
Japanese Patent JP2008502589
Kind Code:
A
Abstract:
Antibodies, humanized antibodies, resurfaced antibodies antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit, insulin-like growth factor-I receptor, antagonize the effects of IGF-I, IGF-II and serum on the growth and survival of tumor cells, and which are substantially devoid of agonist activity. The antibodies and fragments thereof may be used, optionally in conjunction with other therapeutic agents, in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma, prostate cancer and pancreatic cancer and the derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor. ® KIPO & WIPO 2007
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Inventors:
Shin, Rajiva
Danielle Tavares
Doug Digian, Nancy Yee
Danielle Tavares
Doug Digian, Nancy Yee
Application Number:
JP2006543832A
Publication Date:
January 31, 2008
Filing Date:
December 07, 2004
Export Citation:
Assignee:
Immunogen Incorporated
International Classes:
A61K39/395; A61K31/138; A61K31/28; A61K31/337; A61K31/4196; A61K31/427; A61K31/429; A61K31/439; A61K31/4745; A61K31/506; A61K31/513; A61K31/517; A61K31/522; A61K31/53; A61K31/5377; A61K31/565; A61K31/5685; A61K31/573; A61K31/65; A61K31/655; A61K31/675; A61K31/69; A61K31/7028; A61K31/7048; A61K31/7052; A61K31/7068; A61K31/7076; A61K45/00; A61P35/00; C07H19/06; C07K16/28; C07K16/46; C12N15/02
Domestic Patent References:
| JP2005533493A | 2005-11-10 |
Foreign References:
| WO2002053596A2 | 2002-07-11 |
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinobu Fukusho