Title:
【発明の名称】6,9-ジ置換2-[トランス-(4-アミノシクロヘキシル)アミノ]プリン
Document Type and Number:
Japanese Patent JP2002504552
Kind Code:
A
Abstract:
The present invention provides novel compounds of the formula (I)whereinR is selected from the group consisting of R2, R2NH-, or R3R4N-R5- whereinR2 is selected from the group consisting of C9-C12 alkyl,Z is selected from the group consisting of phenyl, heterocycle, cycloalkyl, and naphthanlene; and M is selected from the group consisting of hydrogen, C1-C4 alkyl, andwherein each C9-C12 alkyl or Z is optionally substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting of D, E,wherein each D is independently selected from the group consisting of trifluoromethyl, trifluoromethoxy, and C1-C4 alkoxy; each E is independently selected from the group consisting of Hal, OH, and C1-C8 alkyl;R3 and R4 are selected from the group consisting of hydrogen, C1-C4 alkyl and (CH2)y-phenyl, wherein y is an integer 0-8, with the proviso that R3 and R4 not both be hydrogen;R5 is C1-C8 alkylene; andR1 is selected from the group consisting of cyclopentyl, cyclopentenyl and isopropyl,and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof,with the proviso that when R2 is the groupwherein n is 1 or greater; R1 is isopropyl or cyclopentyl; R6 is hydrogen, C1-C4 alkyl, or (CH2)m-phenyl; and Z is phenyl, heterocycle, or cycloalkyl, that Z is substituted with 1 to 3 substituents, which may be the same or different, and which are selected from the group consisting ofIn addition, the present invention provides a method of inhibiting cyclin dependent kinases, particularly cdk-2.The present invention also provides a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms.
Inventors:
Jennifer A. Dumont
Alan Jay Bitonety
David Earl Bohr Sharding
Norton Pee Pete
H. Rundle Manson
Patrick Double You Kay Shum
Alan Jay Bitonety
David Earl Bohr Sharding
Norton Pee Pete
H. Rundle Manson
Patrick Double You Kay Shum
Application Number:
JP2000533430A
Publication Date:
February 12, 2002
Filing Date:
February 18, 1999
Export Citation:
Assignee:
Aventis Pharmaceuticals Incorporated
International Classes:
A61K31/52; A61P25/00; A61P35/00; A61P35/02; A61P43/00; C07D473/00; C07D473/16; (IPC1-7): C07D473/16; A61K31/52; A61P25/00; A61P35/00; A61P35/02; A61P43/00
Foreign References:
| WO1997016452A1 | 1997-05-09 | |||
| WO1998005335A1 | 1998-02-12 | |||
| WO1997020842A1 | 1997-06-12 |
Attorney, Agent or Firm:
Chika Takagi (2 outside)