Title:
【発明の名称】O-デスメチルベンラファキシンのエーテル
Document Type and Number:
Japanese Patent JP2003514889
Kind Code:
A
Abstract:
This invention provides O- alpha -acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I); wherein the configuration at the steriogenic center (*) may be R, S, or RS (the racemate); R1 is selected from C1-C6 alkyl, C1-C6 alkoxy, C3-C6 cycloalkyl, or the moiety: (a); R2 is selected from H, or C1-C6 alkyl; or, R1 and R2 may be concatenated such that (i), form a moiety having formula (b); R3 is selected from H or C1-C6 alkyl; and R4 and R5 are independently selected from H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 thioalkoxy, -CN, -OH, -CF3, -OCF3, halogen, -NH2, -NO2, or mono or dialkylamino wherein each alkyl group has 1 to 6 carbon atoms, or pharmaceutically acceptable salts or hydrates thereof, R, S, or RS forms thereof; as well as pharmaceutical compositions and methods treating central nervous system disorders.
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Inventors:
John Patrick Yardley
Magid Abdel-Megid Abou-Galvia
John William Woolrich
Magid Abdel-Megid Abou-Galvia
John William Woolrich
Application Number:
JP2001539850A
Publication Date:
April 22, 2003
Filing Date:
November 21, 2000
Export Citation:
Assignee:
Wyeth
International Classes:
A61K31/135; A61K31/222; A61K31/343; A61P13/02; A61P15/10; A61P25/00; A61P25/04; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; C07C213/06; C07D307/89; C07C217/36; C07C217/74; (IPC1-7): C07C217/36; A61K31/222; A61K31/343; A61P13/02; A61P15/10; A61P25/00; A61P25/04; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; C07D307/89
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)