Title:
固体フィブリノーゲンおよび固体トロンビンを有する担体
Document Type and Number:
Japanese Patent JP2004521115
Kind Code:
A
Abstract:
The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm 3 , chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, µ-aminocaproic acid or ±2-antiplasmin,
Inventors:
Stimeder Dagmar
Application Number:
JP2002559083A
Publication Date:
July 15, 2004
Filing Date:
January 25, 2002
Export Citation:
Assignee:
NYCOMED PHARMA AS
International Classes:
A61K38/46; A61K38/48; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61L15/16; A61L15/22; A61L15/32; A61K9/16; A61L15/42; A61L15/44; A61L15/64; A61L24/00; A61L24/08; A61L24/10; A61L27/00; A61L31/04; A61P7/04; A61P41/00; C08H1/06; C08J9/30; C08L89/06; A61L; C08J; C08L; (IPC1-7): A61K38/46; A61K9/16; A61K38/48; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61L24/00; A61P7/04; A61P41/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto