Title:
ヒドロキシアパタイト標的化ポリ(エチレングリコール)および関連重合体
Document Type and Number:
Japanese Patent JP2004522712
Kind Code:
A
Abstract:
Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two termini, a first terminus being covalently bonded to a hydroxyapatite-targeting moiety, such as a bisphosphonate, and a second terminus covalently bonded to a chemically reactive group, wherein said chemically reactive group is protected or unprotected. Methods of preparing and using hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are also provided.
Inventors:
Robert, michael james
Kozlowski, Antoni
Kozlowski, Antoni
Application Number:
JP2002542430A
Publication Date:
July 29, 2004
Filing Date:
October 18, 2001
Export Citation:
Assignee:
Nectar Therapeutics AE, Corporation
International Classes:
C07D453/04; A61K31/49; A61K45/00; A61K47/30; A61K47/32; A61K47/34; A61K47/42; A61K47/48; A61P33/06; C08G85/00; (IPC1-7): A61K47/30; A61K31/49; A61K45/00; A61K47/32; A61K47/34; A61K47/42; A61K47/48; A61P33/06; C08G85/00
Domestic Patent References:
| JPH02268190A | 1990-11-01 | |||
| JPS6226256A | 1987-02-04 | |||
| JPH07500315A | 1995-01-12 |
Foreign References:
| WO1998035704A1 | 1998-08-20 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita