Title:
p38キナーゼ関連疾患の処置方法およびキナーゼインヒビターとして有用なピロロトリアジン化合物
Document Type and Number:
Japanese Patent JP2004522713
Kind Code:
A
Abstract:
Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups ZR4R5 taken together comprise an NH-subsituted aryl.
Inventors:
Katerina Lefferis
Joel Burrish
John Hines
Steven T. Robleski
Joel Burrish
John Hines
Steven T. Robleski
Application Number:
JP2002543494A
Publication Date:
July 29, 2004
Filing Date:
November 07, 2001
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/53; A61K31/5377; A61K31/551; A61P1/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P25/28; A61P29/00; A61P31/14; A61P37/06; A61P39/02; A61P43/00; C07D209/00; C07D253/00; C07D471/00; C07D487/00; C07D487/04; C07D519/00; C07D; (IPC1-7): C07D487/04; A61K31/53; A61K31/5377; A61K31/551; A61P1/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/10; A61P25/28; A61P29/00; A61P31/14; A61P37/06; A61P39/02; A61P43/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Toshio Ueda
Nagatoshi Shinagawa
Toshio Ueda
Nagatoshi Shinagawa
Previous Patent: ヒドロキシアパタイト標的化ポリ（エチレングリコール）および関連重合...
Next Patent: ヘテロ型家族性高コレステロール血症の治療におけるロスバスタチン（Ｚ...
Next Patent: ヘテロ型家族性高コレステロール血症の治療におけるロスバスタチン（Ｚ...