Title:
脂質をベースとする酸化窒素供与体
Document Type and Number:
Japanese Patent JP2004523520
Kind Code:
A
Abstract:
Novel nitric-oxide releasing lipid molecules are provided which comprise a lipid molecule selected from (a) phosphoglycerides, (b) lipids having a sphingosine base as a backbone, (c) monoacylglyerols, (d) diacylglycerols, (e) glycosylacylglycerols, and (f) sterol compounds of the formula: where R is a branched aliphatic chain of eight or more carbon atoms, wherein the lipid molecule is provided with a nitric-oxide containing group which comprises (a) a —S—N═O moiety, (b) a —O—N═O moiety, or (c) a a moiety. Also provided are methods of forming such nitric oxide releasing lipid molecules. Various pharmaceutical compositions, topical liquids and drug delivery systems comprising the nitric-oxide releasing lipid molecules are also described. Further provided are methods for therapeutically administering nitric oxide to patients, methods of treating or preventing various conditions, methods for promoting wound healing and methods of reducing the cells present in an atherosclerotic lesion, which methods utilize the nitric-oxide releasing lipid molecules.
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Inventors:
Herman, Robert, A
Nymark, Wendy
Nymark, Wendy
Application Number:
JP2002557382A
Publication Date:
August 05, 2004
Filing Date:
December 12, 2001
Export Citation:
Assignee:
Said Life Systems, Inc.
International Classes:
C07D295/22; A61F2/82; A61K9/06; A61K9/08; A61K9/127; A61K31/133; A61K31/495; A61K31/575; A61K31/683; A61K31/7012; A61K45/00; A61K45/06; A61L15/44; A61L29/16; A61L31/16; A61M25/00; A61M25/10; A61P9/00; A61P9/10; A61P15/10; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P31/04; A61P35/00; A61P43/00; C07C243/42; C07C291/00; C07C381/00; C07H5/06; C07H11/04; C07J9/00; C07J41/00; (IPC1-7): C07C291/00; A61K9/06; A61K9/08; A61K9/127; A61K31/133; A61K31/495; A61K31/575; A61K31/683; A61K31/7012; A61K45/00; A61M25/00; A61M29/00; A61P9/00; A61P9/10; A61P15/10; A61P17/04; A61P17/06; A61P19/02; A61P31/04; A61P35/00; A61P43/00; C07C381/00; C07D295/22; C07H5/06; C07H11/04; C07J9/00
Attorney, Agent or Firm:
Akira Koike
Eiichi Tamura
Seiji Iga
Eiichi Tamura
Seiji Iga