Title:
治療成分を神経細胞に細胞内送達するための化合物
Document Type and Number:
Japanese Patent JP2005503994
Kind Code:
A
Abstract:
A method for improving intercellular administration of a therapeutic agent is provided comprising: contacting cells with a compound comprising a charged derivative of a therapeutic agent having a therapeutic activity, the charged derivative being conjugated to a protein having a biological activity of being transported across a cell membrane into a cell; and having the cell transport the compound into the cell where the cell metabolizes at least a portion of the compound to form a charged metabolite product that possesses the therapeutic activity of the therapeutic agent, the charged metabolite product being less prone to being transported across the cell membrane out of the cell relative to the compound and less prone to being transported across the cell membrane out of the cell relative to the therapeutic agent.
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Inventors:
Hill Gordon Craig
Karl Stefan Bee.
Web robert
McKee Constance A.
Karl Stefan Bee.
Web robert
McKee Constance A.
Application Number:
JP2002549299A
Publication Date:
February 10, 2005
Filing Date:
November 02, 2001
Export Citation:
Assignee:
Asilomar Pharmaceuticals, Inc.
International Classes:
C12P21/08; A61K31/7088; A61K38/00; A61K39/395; A61K47/48; A61K48/00; A61P17/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/28; A61P31/12; A61P31/22; C07K14/48; C07K14/52; C07K16/18; (IPC1-7): A61K47/48; A61K31/7088; A61K38/00; A61K39/395; A61K48/00; A61P17/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/28; A61P31/12; A61P31/22; C07K14/48; C07K14/52; C07K16/18
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto