Title:
1α-ヒドロキシ-2-メチレン-19-ノル-ホモプレグナカルシフェロールの合成法
Document Type and Number:
Japanese Patent JP2005521742
Kind Code:
A
Abstract:
A method of making 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol. The method includes the steps of condensing a bicyclic ketone with an allylic phosphine oxide to produce a protected 19-nor-pregnacalciferol analog, thereafter cleaving the protecting group to form 22-alcohol, converting the alcohol to an ester, reducing the ester to 17beta-isopropyl-19-nor-vitamin D analog, and finally deprotecting the 17beta-isopropyl derivative to form the desired compound.
Inventors:
Deluca, Hector Ef
Goulgari, Smithra
Rafal Earl
Goulgari, Smithra
Rafal Earl
Application Number:
JP2003582124A
Publication Date:
July 21, 2005
Filing Date:
March 26, 2003
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07C401/00; (IPC1-7): C07C401/00
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya