Title:
アントラキノン消光色素、それらの製造方法及び使用
Document Type and Number:
Japanese Patent JP2006500408
Kind Code:
A
Abstract:
The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can be conjugated to a variety of biologically relevant compounds, including lipids, nucleic acids, polypeptides, and more specifically antigens, steroids, vitamins, drugs, haptens, metabolites, toxins, environmental pollutants, amino acids, peptides, proteins, nucleotides, oligonucleotides, polynucleotides, carbohydrates, and their analogs. The invention also provides kits comprising, in one or more containers, at least one anthraquinone quencher dye composition of the present invention, and instructions for using that composition.
Inventors:
Bake mark aaron
Laker Andrey
Juan Linzian
Rose scott
Yong Yofy
Laker Andrey
Juan Linzian
Rose scott
Yong Yofy
Application Number:
JP2004537958A
Publication Date:
January 05, 2006
Filing Date:
September 19, 2003
Export Citation:
Assignee:
Integrated DNA Technologies, Inc.
International Classes:
C07C225/36; C07F9/09; C07F9/24; C07H21/00; C09B1/26; C12N15/09; C12Q1/68
Other References:
JPN6009049936, Ｍａｙ， Ｊｏｎａｔｈａｎ Ｐ．； Ｂｒｏｗｎ， Ｌｙｎｄａ Ｊ．； Ｂｒｏｗｎ， Ｔｏｍ, "Ｓｙｎｔｈｅｓｉｓ ｏｆ ａ ｎｏｖｅｌ ｄａｒｋ ｑｕｅｎｃｈｅｒ ｆｏｒ ｕｓｅ ｗｉｔｈ ｌｏｎｇ ｗａｖｅｌｅｎｇｔｈ ｄｙｅｓ ｉｎ ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ ｐｒｏｂｅｓ", Ｉｎｎｏｖａｔｉｏｎ ａｎｄ Ｐｅｒｓｐｅｃｔｉｖｅｓ ｉｎ Ｓｏｌｉｄ Ｐｈａｓｅ Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｃｏｍｂｉｎａｔｏｒｉａｌ Ｌｉｂｒａｒｉｅｓ： Ｐｅｐｔｉｄｅｓ， Ｐｒｏｔｅｉｎｓ, 2002, ２００１, ２３１−２３４
JPN6009049937, Ｍｏｒｉ， Ｋｅｎｙａ； Ｓｕｂａｓｉｎｇｈｅ， Ｃｈｒｉｓａｎｔｈｉ； Ｃｏｈｅｎ， Ｊａｃｋ Ｓ．, "Ｏｌｉｇｏｄｅｏｘｙｎｕｃｌｅｏｔｉｄｅ ａｎａｌｏｇｓ ｗｉｔｈ ５’−ｌｉｎｋｅｄ ａｎｔｈｒａｑｕｉｎｏｎｅ", ＦＥＢＳ Ｌｅｔｔｅｒｓ, 1989, ２４９（２）, ２１３−１８
JPN6009049938, Ｇｉｂｓｏｎ， Ｖ．； Ａｎｄｅｒｓｏｎ， Ｒ． Ｊ．； Ｂｒｏｗｎ， Ｊ． Ｒ．； Ｍａｃｋａｙ， Ｓ． Ｐ．； Ｃａｉｒｎｓ， Ｄ．, "Ｍｏｌｅｃｕｌａｒ ｍｏｄｅｌｉｎｇ ｏｆ ａｎｔｈｒａｑｕｉｎｏｎｅ−ｏｌｉｇｏｄｅｏｘｙｎｕｃｌｅｏｔｉｄｅ ｃｏｎｊｕｇａｔｅｓ", Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ, 1996, ２（１１）, ５４５−５４８
JPN6009049939, Ｍｏｒｉｅｒ−Ｔｅｉｓｓｉｅｒ， Ｅ． 他, "Ｆｒｅｅ ｒａｄｉｃａｌ ｐｒｏｄｕｃｔｉｏｎ ａｎｄ ＤＮＡ ｃｌｅａｖａｇｅ ｂｙ ｃｏｐｐｅｒ ｃｈｅｌａｔｉｎｇ ｐｅｐｔｉｄｅ−ａｎｔｈｒａｑｕｉｎｏｎｅｓ", Ａｎｔｉ−Ｃａｎｃｅｒ Ｄｒｕｇ Ｄｅｓｉｇｎ, 1990, ５（３）, ２９１−３０５
JPN6009049937, Ｍｏｒｉ， Ｋｅｎｙａ； Ｓｕｂａｓｉｎｇｈｅ， Ｃｈｒｉｓａｎｔｈｉ； Ｃｏｈｅｎ， Ｊａｃｋ Ｓ．, "Ｏｌｉｇｏｄｅｏｘｙｎｕｃｌｅｏｔｉｄｅ ａｎａｌｏｇｓ ｗｉｔｈ ５’−ｌｉｎｋｅｄ ａｎｔｈｒａｑｕｉｎｏｎｅ", ＦＥＢＳ Ｌｅｔｔｅｒｓ, 1989, ２４９（２）, ２１３−１８
JPN6009049938, Ｇｉｂｓｏｎ， Ｖ．； Ａｎｄｅｒｓｏｎ， Ｒ． Ｊ．； Ｂｒｏｗｎ， Ｊ． Ｒ．； Ｍａｃｋａｙ， Ｓ． Ｐ．； Ｃａｉｒｎｓ， Ｄ．, "Ｍｏｌｅｃｕｌａｒ ｍｏｄｅｌｉｎｇ ｏｆ ａｎｔｈｒａｑｕｉｎｏｎｅ−ｏｌｉｇｏｄｅｏｘｙｎｕｃｌｅｏｔｉｄｅ ｃｏｎｊｕｇａｔｅｓ", Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ, 1996, ２（１１）, ５４５−５４８
JPN6009049939, Ｍｏｒｉｅｒ−Ｔｅｉｓｓｉｅｒ， Ｅ． 他, "Ｆｒｅｅ ｒａｄｉｃａｌ ｐｒｏｄｕｃｔｉｏｎ ａｎｄ ＤＮＡ ｃｌｅａｖａｇｅ ｂｙ ｃｏｐｐｅｒ ｃｈｅｌａｔｉｎｇ ｐｅｐｔｉｄｅ−ａｎｔｈｒａｑｕｉｎｏｎｅｓ", Ａｎｔｉ−Ｃａｎｃｅｒ Ｄｒｕｇ Ｄｅｓｉｇｎ, 1990, ５（３）, ２９１−３０５
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama