Title:
表面処理方法
Document Type and Number:
Japanese Patent JP2006512065
Kind Code:
A
Abstract:
A biosensor comprising surface treated with a method for producing a monolayer of molecules on a surface, the method comprising loading a stamp with seed molecules, transferring seed molecules from the stamp to the surface, wherein transferring comprises transferring a fraction of the seed molecules loaded on the stamp to the surface and adsorbing the seed molecules to the stamp and adsorbing the seed molecules to the surface, the adsorption of the seed molecules to the stamp being stronger than the adsorption of the seed molecules to the surface, self-completing amplification of the seed molecules via an amplifying reaction to produce the monolayer on a flat surface, wherein self-completing amplification comprises producing a homogeneous area, wherein the homogeneous area comprises a monolayer of molecules on the surface, and wherein the monolayer of molecules on the surface has no diffusive component that can relocate and destroy amplification accuracy.
Inventors:
Amontov, Sergey
De la Marche, Emanuel
Michel, Bruno
De la Marche, Emanuel
Michel, Bruno
Application Number:
JP2004561736A
Publication Date:
April 13, 2006
Filing Date:
November 13, 2003
Export Citation:
Assignee:
INTERNATIONAL BUSINESS MASCHINES CORPORATION
International Classes:
C12M1/00; B01J19/00; C12Q1/68; G01N33/53; G01N33/543; C12N15/09
Domestic Patent References:
| JP2001519538A | 2001-10-23 | |||
| JP2002543847A | 2002-12-24 | |||
| JPH10510158A | 1998-10-06 |
Foreign References:
| US6423552B1 | 2002-07-23 |
Other References:
JPN6009044657, Ｂｉｏｍａｔｅｒｉａｌｓ， ｖｏｌ． ２０， ｐａｇｅｓ ２３６３−２３７６ （１９９９）
Attorney, Agent or Firm:
Hiroshi Sakaguchi
Yoshihiro City
Takeshi Ueno
Yoshihiro City
Takeshi Ueno