Title:
LNA-CpGコンジュゲート
Document Type and Number:
Japanese Patent JP2006512064
Kind Code:
A
Abstract:
The present invention relates to novel compositions comprising DNA attached to an immunostimulatory oligonucleotide (CpG) via a locked nucleic acid oligonucleotide of a defined sequence. In particular the present invention provides compositions comprising a plasmid containing a gene encoding a protein of interest, wherein said plasmid may be introduced to a tissue or cell and the gene expressed, complexed to the LNA-CpG. Also provided is a method of co-synthesis of CpG and LNA to form compositions for use as adjuvants with DNA plasmid vaccines.
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Inventors:
Catch pole, ian, richard
Application Number:
JP2004558012A
Publication Date:
April 13, 2006
Filing Date:
December 04, 2003
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
C12N15/09; C12N15/117; A61K39/00; A61K48/00
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai