Title:
網膜虚血の治療におけるジアゾキシドの使用
Document Type and Number:
Japanese Patent JP2006519821
Kind Code:
A
Abstract:
The use of pharmaceutical compositions containing diazoxide (I) (i.e. 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide) is claimed in the production of medicaments for the treatment and/or prevention of diseases associated with retinal ischemia. ACTIVITY : Ophthalmological; vasotropic; antidiabetic. In tests in rats with retinal ischemia, local administration of 10 Microl of 0.01% solution of (I) to the conjunctival sac 30 minutes after the start of reperfusion and every day for 4 days caused almost complete recovery of electrical activity in the retina after 3 days (A and B wave amplitudes 97.01% and 96.36% respectively of the initial values). In controls without the treatment with (I), the A and B wave amplitudes were 40.55% and 31.88% respectively of the initial values 7 days after the start of reperfusion. MECHANISM OF ACTION : Adenosine triphosphate (ATP)-dependent channel opener.
Inventors:
Razo Dunski Mitchell
ETCHE Mohamed
ETCHE Mohamed
Application Number:
JP2006505715A
Publication Date:
August 31, 2006
Filing Date:
March 11, 2004
Export Citation:
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS)
UNIVERSITE DE NICE-SOPHIA ANTIPOLIS
UNIVERSITE DE NICE-SOPHIA ANTIPOLIS
International Classes:
A61K31/549; A61K9/08; A61K31/428; A61P9/10; A61P27/02; A61P27/06; A61P43/00; C07D285/24
Foreign References:
| WO1994025033A1 | 1994-11-10 | |||
| WO1999042103A1 | 1999-08-26 | |||
| WO1998029135A1 | 1998-07-09 |
Attorney, Agent or Firm:
Masago Onishi
Nobuyuki Yamaguchi
Nobuyuki Yamaguchi