Title:
新規カルバモイルおよびチオカルバモイルホスフォネート類、およびそれらを含む医薬組成物
Document Type and Number:
Japanese Patent JP2006522108
Kind Code:
A
Abstract:
The present invention provides a compound of the following formula I: R3-NH-C(-X)-P(-O)OR1OR2 including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically active forms of the compounds of formula I and pharmaceutically acceptable salts, solvates, hydrates and polymorphs of said isomers and forms, wherein R1 and R2 may be the same or different and are each selected from hydrogen, acyloxyalkyl and aryl or R1 and R2 may form together with the oxygen and phosphorus atoms a dioxaphosphacycloalkane ring; X is O or S; and R3 is selected, when X is O, from bicycloalkyl, cycloalkylalkyl and substituted cycloalkyl by at least one of alkyl, amino, amidino and guanidino; and R3 is selected, when X is S, from bicycloalkyl, cycloalkylalkyl and cycloalkyl optionally substituted by at least one of alkyl, amino, amidino and guanidino; with the proviso that: when X is O, R3 is not cyclohexylmethyl, and when X is S, R3 is not cyclohexyl. The invention further provides pharmaceutical compositions comprising the above compounds and their use in medicine.
Inventors:
Brewer Eri
Reich Ruben
Goromb Garsion
Katz Ifat
Reich Ruben
Goromb Garsion
Katz Ifat
Application Number:
JP2006507598A
Publication Date:
September 28, 2006
Filing Date:
April 01, 2004
Export Citation:
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
International Classes:
C07F9/38; A61K31/662; A61P9/00; A61P19/02; A61P25/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Masahiro Okada