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Title:
ras-ファルネシルトランスフェラーゼ阻害剤、シクロデキストリンおよびエタノールの複合体
Document Type and Number:
Japanese Patent JP2006525341
Kind Code:
A
Abstract:
A ras-farnesyltransferase inhibitor complex formed from a ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof, a substituted cyclodextrin, and ethanol is provided. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor, improved dissolution, enhanced stability and is essentially free of particulate matter.

Inventors:
Anne Marie Smith
Michael Cucolo
Munil N Nassar
Application Number:
JP2006513402A
Publication Date:
November 09, 2006
Filing Date:
April 27, 2004
Export Citation:
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Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/5513; A61K9/08; A61K31/715; A61K31/724; A61K47/10; A61K47/40; A61P35/00; A61P43/00; A61K
Domestic Patent References:
JP2002535253A2002-10-22
JPH10508836A1998-09-02
JPH06506500A1994-07-21
JPH02705A1990-01-05
JPS62103077A1987-05-13
Attorney, Agent or Firm:
Kyousei Tamura
Yushiro Tsuboi
Masahiro Nitta



 
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