Title:
回折格子結合導波路の感度向上のための基板屈折率変更
Document Type and Number:
Japanese Patent JP2007501432
Kind Code:
A
Abstract:
A grating-coupled waveguide (GCW) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the GCW. The GCW includes a substrate, a diffraction grating and a waveguide film that has a higher index of refraction than the substrate which has an index of refraction<=1.5. The relatively low-index substrate effectively increases the sensitivity of the GCW by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the GCWs are incorporated within the wells of a microplate.
Inventors:
Caratch, Stephan Jay
Mos Dee, Eric Jay
Despa, Millsea
Saliku, Mark Dee
Mos Dee, Eric Jay
Despa, Millsea
Saliku, Mark Dee
Application Number:
JP2006522557A
Publication Date:
January 25, 2007
Filing Date:
June 25, 2004
Export Citation:
Assignee:
CORNING INCORPORATED
International Classes:
G02B6/122; G01N21/03; G01N21/27; G01N21/77; G02B5/18
Foreign References:
| WO1990008318A1 | 1990-07-26 | |||
| US20030027328A1 | 2003-02-06 | |||
| EP1031828A1 | 2000-08-30 |
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma