Title:
酸性αグルコシダーゼおよびそのフラグメント
Document Type and Number:
Japanese Patent JP2007521818
Kind Code:
A
Abstract:
Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells, and methods relating to the practice of the invention are also provided.
Inventors:
Lebowitz, Jonathan
Maga, john
Maga, john
Application Number:
JP2006552375A
Publication Date:
August 09, 2007
Filing Date:
February 10, 2005
Export Citation:
Assignee:
Zeistor Therapeutics, Incorporated
International Classes:
C12N15/09; A61K38/00; A61K38/47; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12N9/24; C12N9/26; C12N15/62; C12P21/04
Foreign References:
| WO2002087510A2 | 2002-11-07 | |||
| WO2003032727A1 | 2003-04-24 | |||
| WO2003086452A2 | 2003-10-23 | |||
| WO2003102583A1 | 2003-12-11 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita