Title:
ヘッジホッグシグナル伝達のキノキサリン阻害剤
Document Type and Number:
Japanese Patent JP2007535569
Kind Code:
A
Abstract:
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A is a carbocycle or heterocycle; X is alkylene, NR4C(O), NR4C(S), NR4C(NH), NR4SO, NR4SO2, NR4C(O)NH, NR4C(S)NH, C(O)NR4, C(S)NR4, C(NH)NR4, NR4PO or NR4PO(OH) wherein R4 is H or alkyl; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl or a heterocycle each of which is optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R2 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R3 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; m is 0-3; n is 0-3; and salts and solvates thereof. The invention also provides methods of using these compounds for therapy and/or prophylaxis in a mammal of hyperproliferative diseases and angiogenesis mediated diseases due to their activity for inhibiting the hedgehog signaling pathway.
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Inventors:
Kohler, Michael F. Tee.
Goldsmith, Richard
Sutherin, Daniel Pee.
Goldsmith, Richard
Sutherin, Daniel Pee.
Application Number:
JP2007511079A
Publication Date:
December 06, 2007
Filing Date:
April 29, 2005
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C07D241/42; A61K31/498; A61P35/00; A61P43/00; C07D401/12
Foreign References:
| GB1198301A | 1970-07-08 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Shintaro Koike
Takashi Ishida
Fukumoto product
Tetsuji Koga
Shintaro Koike