Title:
WRN媒介性テロメア開始型細胞シグナル伝達の調節
Document Type and Number:
Japanese Patent JP2007537758
Kind Code:
A
Abstract:
The invention relates to a composition comprising an activator or inhibitor of WRN for use as a medicament, wherein the use comprises the treatment of cancer, the inducement of apoptosis, inducing cellular senescence treatment of promoting tanning, promoting cellular differentiation or promoting immunosuppression. The activator or inhibitor can be an oligonucleotide activator or inhibitor of WRN with at least 33% nucleotide sequence identity with (TTAGGG) n and at least the first x 3'-nucleotide linkages are hydrolyzable by a 3' to 5' nuclease, wherein n=1 to 20, and wherein x is from about 0 to about 10.
Inventors:
Gil Crest, Barbara A.
Error, Mark S.
Error, Mark S.
Application Number:
JP2007527438A
Publication Date:
December 27, 2007
Filing Date:
May 19, 2005
Export Citation:
Assignee:
TRUSTEES OF BOSTON UNIVERSITY
International Classes:
C12Q1/02; A61K31/711; A61K45/00; A61P35/00; A61P37/06; A61P43/00; C12N9/14; C12N15/113; G01N33/15; G01N33/50; G01N33/68
Domestic Patent References:
| JP2002515735A | 2002-05-28 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita