Title:
灌流三次元細胞/組織疾患モデル
Document Type and Number:
Japanese Patent JP2007537759
Kind Code:
A
Abstract:
A system has been constructed that recapitulate the features of a capillary bed through normal human tissue. The system facilitates perfusion of three-dimensional (3D) cell monocultures and heterotypic cell co-cultures at the length scale of the capillary bed. A major feature is that the system can be utilized within a multiwell plate format amenable to high-throughput assays compatible with the type of robotics commonly used in pharmaceutical development. The system provides a means to conduct assays for toxicology and metabolism and as a model for human diseases such as hepatic diseases, including hepatitis, exposure-related pathologies, and cancer. Cancer applications include primary liver cancer as well as metastases. The system can also be used as a means of testing gene therapy approaches for treating disease and inborn genetic defects.
More Like This:
Inventors:
Doman Skye, Karel
Griffith, Lindsey.
Tannen Baume, Stephen Earl.
Wales, Alan
Griffith, Lindsey.
Tannen Baume, Stephen Earl.
Wales, Alan
Application Number:
JP2007527446A
Publication Date:
December 27, 2007
Filing Date:
May 19, 2005
Export Citation:
Assignee:
Massachusetts Institute of Technology
University of Pittsburgh of the Commonwealth System of Higher Education
University of Pittsburgh of the Commonwealth System of Higher Education
International Classes:
C12M3/00; B01L3/00; C12M1/00; C12M1/32; C12M1/34; C12M3/06; C12Q1/68
Foreign References:
| US20030215941A1 | 2003-11-20 | |||
| WO2004038367A2 | 2004-05-06 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita