Title:
ガン化学療法薬として有用な2-アミノアリールカルボキシアミド
Document Type and Number:
Japanese Patent JP2008504285
Kind Code:
A
Abstract:
A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.
Inventors:
Brennan, Kyasarin
Dixon, Julie A
Scott, William J.A.
Redman, Anico
The Johns, Benjamin Day
Phillipps, Burton
Wickens, Philip
Anyday, Istvan
Kumarashinge, Elara Heuage
Clyman, Challes
Deyumas, Jack
Kille, Uday
Chiyuan, Chi-yuan
Kruender, Harold Sea Yi
Hong, tsuenshiu
Wang, Ray
Belar, donald
Dixon, Julie A
Scott, William J.A.
Redman, Anico
The Johns, Benjamin Day
Phillipps, Burton
Wickens, Philip
Anyday, Istvan
Kumarashinge, Elara Heuage
Clyman, Challes
Deyumas, Jack
Kille, Uday
Chiyuan, Chi-yuan
Kruender, Harold Sea Yi
Hong, tsuenshiu
Wang, Ray
Belar, donald
Application Number:
JP2007518319A
Publication Date:
February 14, 2008
Filing Date:
June 23, 2005
Export Citation:
Assignee:
Bayer Pharmaceuticals Corporates Corporation
International Classes:
C07D405/12; A61K31/443; A61K31/4433; A61K31/4545; A61K31/506; A61K31/5377; A61K31/55; A61P35/00; C07D405/14; C07D409/14; C07D417/14
Foreign References:
| WO2004007458A1 | 2004-01-22 | |||
| WO2002066470A1 | 2002-08-29 |
Attorney, Agent or Firm:
Heikichi Odashima