Title:
ヒトレプチン由来のポリペプチドとその使用
Document Type and Number:
Japanese Patent JP2008535797
Kind Code:
A
Abstract:
Leptin controls the production of C-Reactive Protein (CRP), which, in turn, interacts with leptin to diminish its ability to signal satiety and reduce food intake. The interactions between leptin and CRP can be exploited to screen for agents capable of disrupting the leptin-CRP interaction, and thereby improve leptin signaling. Such agents can be used to reduce body weight, adiposity, and alleviate insulin resistance and diabetes.
Inventors:
Zao, Alan, Zet.
Application Number:
JP2008500945A
Publication Date:
September 04, 2008
Filing Date:
March 09, 2006
Export Citation:
Assignee:
The University of Pittsburgh of the Commonwealth System
International Classes:
C07K14/47; A61K31/7088; A61K38/00; A61P3/04; A61P3/10; A61P9/10; A61P15/00; A61P29/00; C12Q1/48; C12N15/09
Foreign References:
| US6849714B1 | 2005-02-01 | |||
| WO1996035787A1 | 1996-11-14 | |||
| WO1996023520A1 | 1996-08-08 | |||
| US20050038609A1 | 2005-02-17 | |||
| WO1997006816A1 | 1997-02-27 | |||
| WO1996031526A1 | 1996-10-10 | |||
| WO1997016550A1 | 1997-05-09 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai