Title:
VEGFの阻害による貧血の処置
Document Type and Number:
Japanese Patent JP2008535798
Kind Code:
A
Abstract:
Methods of treating anemic disorders in human subjects comprising administering a VEGF antagonist comprising a fusion polypeptide having an immunoglobulin-like (Ig) domain 2 of the VEGF receptor Flt1 and Ig domain 3 of the VEGF receptor Flk1 or Flt4, and a multimerizing component. Further included are methods of preventing anemia, increasing hematocrit levels, and increasing or stimulating erythropoietin, particularly in subjects being treated for cancer with chemotherapeutic agents and/or radiation.
Inventors:
Horash joslin
Sedalbaum Jesse M.
Ludge John
Jankopoulos George Dee.
Star Neil
Sedalbaum Jesse M.
Ludge John
Jankopoulos George Dee.
Star Neil
Application Number:
JP2008500972A
Publication Date:
September 04, 2008
Filing Date:
March 10, 2006
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
A61K45/00; A61K38/00; A61P7/00; A61P7/06; A61P13/12; A61P35/00; A61P43/00; C07K14/71; C07K19/00; C12N15/09
Foreign References:
| WO2005016369A1 | 2005-02-24 |
Other References:
JPN6011030227; ＴＡＭ Ｂ．Ｙ．Ｙ． ｅｔ ａｌ: 'Ｈｙｐｏｘｉａ-Ｉｎｄｅｐｅｎｄｅｎｔ Ｒｅｇｕｌａｔｉｏｎ ｏｆ Ｈｅｐａｔｉｃ Ｅｒｙｔｈｒｏｐｏｉｅｔｉｎ Ｐｒｏｄｕｃｔｉｏｎ ｂｙ Ｖａｓｃｕｌａｒ Ｅｎｄｏｔｈｅｌｉａｌ Ｇｒｏｗｔｈ Ｆ' Ｂｌｏｏｄ Ｖｏｌ．１０４, 2004, ｐ．５９５ａ， ａｂｓｔｒａｃｔ＃２１６３
JPN7011002112; ＲＩＣＨＡＲＤ，Ｓ． ｅｔ ａｌ: 'Ｐａｒａｄｏｘｉｃａｌ ｓｅｃｏｎｄａｒｙ ｐｏｌｙｃｙｔｈｅｍｉａ ｉｎ ｖｏｎ Ｈｉｐｐｅｌ-Ｌｉｎｄａｕ ｐａｔｉｅｎｔｓ ｔｒｅａｔｅｄ ｗｉｔｈ ａｎｔｉ-ｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌ' Ｂｌｏｏｄ Ｖｏｌ．９９， Ｎｏ．１０, 2002, ｐ．３８５１-３
JPN7012000905; ＫＡＤＯＴＡ，Ｔ． ｅｔ ａｌ: 'Ｔｏｘｉｃｉｔｙ ｓｔｕｄｉｅｓ ｏｆ ｐａｃｌｉｔａｘｅｌ． （ＩＩ）--Ｏｎｅ-ｍｏｎｔｈ ｉｎｔｅｒｍｉｔｔｅｎｔ ｉｎｔｒａｖｅｎｏｕｓ ｔｏｘｉｃｉｔｙ ｉｎ ｒａｔｓ］' Ｊ Ｔｏｘｉｃｏｌ Ｓｃｉ Ｖｏｌ．１９ Ｓｕｐｐｌ １, 1994, ｐ．１１-３４
JPN7012000906; ＫＡＤＯＴＡ，Ｔ． ｅｔ ａｌ: 'Ｔｏｘｉｃｉｔｙ ｓｔｕｄｉｅｓ ｏｆ ｐａｃｌｉｔａｘｅｌ． （ＩＩＩ）--Ｓｉｘ-ｍｏｎｔｈ ｉｎｔｅｒｍｉｔｔｅｎｔ ｉｎｔｒａｖｅｎｏｕｓ ｔｏｘｉｃｉｔｙ ｉｎ ｒａｔｓ］' Ｊ Ｔｏｘｉｃｏｌ Ｓｃｉ Ｖｏｌ．１９ Ｓｕｐｐｌ １, 1994, ｐ．３５-５５
JPN7012000907; ＭＡＲＫ，Ｍ． ｅｔ ａｌ: 'Ｃｏｍｍｅｒｃｉａｌ ｔａｘａｎｅ ｆｏｒｍｕｌａｔｉｏｎｓ ｉｎｄｕｃｅ ｓｔｏｍａｔｏｃｙｔｏｓｉｓ ａｎｄ ｉｎｃｒｅａｓｅ ｂｌｏｏｄ ｖｉｓｃｏｓｉｔｙ' Ｂｒ Ｊ Ｐｈａｒｍａｃｏｌ Ｖｏｌ．１３４， Ｎｏ．６, 2001, ｐ．１２０７-１４
JPN6012062923; ステッドマン医学大事典第５版 , 2004, ｐ．１３９８
JPN7011002112; ＲＩＣＨＡＲＤ，Ｓ． ｅｔ ａｌ: 'Ｐａｒａｄｏｘｉｃａｌ ｓｅｃｏｎｄａｒｙ ｐｏｌｙｃｙｔｈｅｍｉａ ｉｎ ｖｏｎ Ｈｉｐｐｅｌ-Ｌｉｎｄａｕ ｐａｔｉｅｎｔｓ ｔｒｅａｔｅｄ ｗｉｔｈ ａｎｔｉ-ｖａｓｃｕｌａｒ ｅｎｄｏｔｈｅｌ' Ｂｌｏｏｄ Ｖｏｌ．９９， Ｎｏ．１０, 2002, ｐ．３８５１-３
JPN7012000905; ＫＡＤＯＴＡ，Ｔ． ｅｔ ａｌ: 'Ｔｏｘｉｃｉｔｙ ｓｔｕｄｉｅｓ ｏｆ ｐａｃｌｉｔａｘｅｌ． （ＩＩ）--Ｏｎｅ-ｍｏｎｔｈ ｉｎｔｅｒｍｉｔｔｅｎｔ ｉｎｔｒａｖｅｎｏｕｓ ｔｏｘｉｃｉｔｙ ｉｎ ｒａｔｓ］' Ｊ Ｔｏｘｉｃｏｌ Ｓｃｉ Ｖｏｌ．１９ Ｓｕｐｐｌ １, 1994, ｐ．１１-３４
JPN7012000906; ＫＡＤＯＴＡ，Ｔ． ｅｔ ａｌ: 'Ｔｏｘｉｃｉｔｙ ｓｔｕｄｉｅｓ ｏｆ ｐａｃｌｉｔａｘｅｌ． （ＩＩＩ）--Ｓｉｘ-ｍｏｎｔｈ ｉｎｔｅｒｍｉｔｔｅｎｔ ｉｎｔｒａｖｅｎｏｕｓ ｔｏｘｉｃｉｔｙ ｉｎ ｒａｔｓ］' Ｊ Ｔｏｘｉｃｏｌ Ｓｃｉ Ｖｏｌ．１９ Ｓｕｐｐｌ １, 1994, ｐ．３５-５５
JPN7012000907; ＭＡＲＫ，Ｍ． ｅｔ ａｌ: 'Ｃｏｍｍｅｒｃｉａｌ ｔａｘａｎｅ ｆｏｒｍｕｌａｔｉｏｎｓ ｉｎｄｕｃｅ ｓｔｏｍａｔｏｃｙｔｏｓｉｓ ａｎｄ ｉｎｃｒｅａｓｅ ｂｌｏｏｄ ｖｉｓｃｏｓｉｔｙ' Ｂｒ Ｊ Ｐｈａｒｍａｃｏｌ Ｖｏｌ．１３４， Ｎｏ．６, 2001, ｐ．１２０７-１４
JPN6012062923; ステッドマン医学大事典第５版 , 2004, ｐ．１３９８
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi