Title:
HGFβ鎖変異体
Document Type and Number:
Japanese Patent JP2008536500
Kind Code:
A
Abstract:
The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators.
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Inventors:
Kirchhofer, Daniel Kay.
Lazarus, Robert A.
Weissman, Christian
Lazarus, Robert A.
Weissman, Christian
Application Number:
JP2008506827A
Publication Date:
September 11, 2008
Filing Date:
April 17, 2006
Export Citation:
Assignee:
GENENTECH,INC.
International Classes:
C12N15/09; A61K38/22; A61P35/00; A61P43/00; C07K14/475; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Foreign References:
| WO2005001486A1 | 2005-01-06 |
Other References:
JPN6011042130; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． ２７９（３８）, 2004, ３９９１５-２４
JPN6011042128; ＥＭＢＯ Ｊ． １１（７）, 1992, ２５０３-１０
JPN6011042130; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． ２７９（３８）, 2004, ｐ．３９９１５-２４
JPN6011042128; ＥＭＢＯ Ｊ． １１（７）, 1992, ２５０３-１０
JPN6011042130; Ｊ． Ｂｉｏｌ． Ｃｈｅｍ． ２７９（３８）, 2004, ｐ．３９９１５-２４
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori