Title:
アスパルチルプロテアーゼインヒビター
Document Type and Number:
Japanese Patent JP2009513670
Kind Code:
A
Abstract:
Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W, R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.
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Inventors:
Chu, Chaonin
Stamford, Andrew W.
Brian mckitrick
Stamford, Andrew W.
Brian mckitrick
Application Number:
JP2008538053A
Publication Date:
April 02, 2009
Filing Date:
October 30, 2006
Export Citation:
Assignee:
Schering Corporation
International Classes:
C07D413/04; A61K31/553; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P25/28; A61P31/10; A61P31/18; A61P33/06; A61P35/00; A61P43/00
Domestic Patent References:
| JP2005516967A | 2005-06-09 |
Foreign References:
| WO2005058311A1 | 2005-06-30 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita