Title:
ラパマイシン類似体及びパクリタキセルを含む組成物及び薬物送達システム
Document Type and Number:
Japanese Patent JP2010500404
Kind Code:
A
Abstract:
The present invention provides for drug-delivery systems and compositions comprising zotarolimus and paclitaxel, or derivatives, prodrugs or salts thereof, as well as methods of treatment using such systems and compositions, wherein the drugs complement each other in effect and/or activity. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and drug-delivery systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.
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Inventors:
Bake, Sandra E.
Chromak, Keith Earl.
Mac, matthew
Toner, John El.
Chromak, Keith Earl.
Mac, matthew
Toner, John El.
Application Number:
JP2009524621A
Publication Date:
January 07, 2010
Filing Date:
August 07, 2007
Export Citation:
Assignee:
Abbott Laboratories
International Classes:
A61K31/337; A61K9/14; A61K31/436; A61K39/395; A61K45/00; A61L31/00; A61P1/16; A61P7/02; A61P7/04; A61P9/00; A61P9/10; A61P13/02; A61P21/00; A61P43/00
Domestic Patent References:
| JP2004154541A | 2004-06-03 | |||
| JP2009511165A | 2009-03-19 | |||
| JP5285426B2 | 2013-09-11 | |||
| JP2004154541A | 2004-06-03 |
Foreign References:
| WO2004112864A2 | 2004-12-29 | |||
| WO2005089855A1 | 2005-09-29 | |||
| WO2006050170A2 | 2006-05-11 | |||
| WO2004112864A2 | 2004-12-29 | |||
| WO2005089855A1 | 2005-09-29 |
Attorney, Agent or Firm:
Yoshinori Shimizu
Takashi Mikami
Ikeda adult
Kimoto
Takashi Mikami
Ikeda adult
Kimoto
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