Title:
7,8-飽和-4,5-エポキシ-モルフィナニウム類似体
Document Type and Number:
Japanese Patent JP2010510329
Kind Code:
A
Abstract:
Novel (R)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (R)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, opioid-induced constipation.
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Inventors:
Perez, Julio
Han, Akimui
Roshtein, Jacob
Han, Akimui
Roshtein, Jacob
Application Number:
JP2009538524A
Publication Date:
April 02, 2010
Filing Date:
November 21, 2007
Export Citation:
Assignee:
Progenics Pharmaceuticals Inc.
International Classes:
C07D489/08; A61K9/08; A61K9/19; A61K9/20; A61K9/22; A61K9/30; A61K31/485; A61K45/00; A61P1/12; A61P11/00; A61P11/06; A61P25/04; A61P25/22; A61P43/00
Attorney, Agent or Firm:
Warren G. Simor