Title:
オキサゾールチロシンキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2010526800
Kind Code:
A
Abstract:
The invention provides a compound which is an amide of the formula (1), or a salt, solvate, N-oxide or tautomer thereof; wherein: a is 0 or 1; b is 0 or 1: provided that the sum of a and b is 0 or 1; T is O or NH Ar1 is a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S, and being optionally substituted by one or more substituents R1; Ar2 Js a monocyclic or bicyclic 5- to 10-membered aryl or heteroaryl group containing up to 4 heteroatoms selected from O, N and S and being optionally substituted by one or more substituents R2; and R1 and R2 are as defined in the claims. The compounds are inhibitors of kinases and in particular FLT3, FLT4 and Aurora kinases.
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Inventors:
John Charles Leader
John Mark Errard
Helen Boffey
Suzanne Taylor
Andrew David Kerr
Michael cherry
Michelle Wilson
Richard Bauquet Ower
John Mark Errard
Helen Boffey
Suzanne Taylor
Andrew David Kerr
Michael cherry
Michelle Wilson
Richard Bauquet Ower
Application Number:
JP2010506999A
Publication Date:
August 05, 2010
Filing Date:
May 09, 2008
Export Citation:
Assignee:
SAREUM LIMITED
International Classes:
C07D233/90; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/421; A61K31/422; A61K31/439; A61K31/4439; A61K31/454; A61K31/4709; A61K31/497; A61K31/5377; A61K31/5513; A61P11/06; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D263/34; C07D401/04; C07D403/04; C07D409/04; C07D413/04; C07D413/12; C07D413/14; C07D451/04; C07D453/02; C07D471/04
Domestic Patent References:
| JP2004512365A | 2004-04-22 | |||
| JP2006506330A | 2006-02-23 | |||
| JP2004501914A | 2004-01-22 | |||
| JP2007509130A | 2007-04-12 |
Foreign References:
| WO2007043400A1 | 2007-04-19 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Masayuki Nakagawa
Yasushi Ochiai
Takuji Yamada
Mitsutaka Iwasaki
Masayuki Nakagawa
Yasushi Ochiai