ワクチンで使用するための、子宮頸部悪性腫瘍に浸潤するT細胞によって標的とされるHPVエピトープ

Japanese Patent JP2010527630

A

The present invention relates to novel CD4+ and CD8+ T cell epitopes that are specific for HPV-specific E6 and E7 oncoproteins, to peptides comprising these novel T cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of HPV related diseases. Preferred epitopes are recognized by a T cell that infiltrates a cervical neoplastic lesion or by a T cell from a draining lymph node, and are presented by an HLA-DQ or HLA-DP molecule, or an HLA-B.

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Van der Burg Solden Henrykas
Kentel Genmagy.
Merifu Cornelis Johannes Maria

JP2010510240A

August 19, 2010

May 27, 2008

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ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC

C12N15/09; A61K39/12; A61P31/12; C07K14/025; C12N5/10

JP2004535816A	2004-12-02
JP2004525115A	2004-08-19
JPH04217998A	1992-08-07
JPH06169781A	1994-06-21

US20050142541A1

2005-06-30

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JPN6013010179; Ｄａｔａｂａｓｅ　ＧｅｎＢａｎｋ , 20010104, ＡＦ３２７８５１
JPN6013010182; Ｉｎｔ．　Ｊ．　Ｃａｎｃｅｒ ｖｏｌ．９７, 2002, ｐｐ．８６８-８７４
JPN6013010183; Ｄａｔａｂａｓｅ　ＧｅｎＢａｎｋ , 20061031, Ｑ９１９Ｂ２
JPN6013010186; Ｉｎｔ．　Ｊ．　Ｃａｎｃｅｒ ｖｏｌ．９１, 2001, ｐｐ．６１２-６１８
JPN6013010188; Ｉｎｔ．　Ｊ．　Ｃａｎｃｅｒ ｖｏｌ．１１４, 2005, ｐｐ．２７４-２８２
JPN6013010191; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｉｍｍｕｎｏｌｏｇｙ ｖｏｌ．１６９, 2002, ｐｐ．３５０-３５８

Masaki Hirota

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