Title:
α2Bおよび/またはα2Cアドレナリン受容体のサブタイプ選択的モジュレーターとしての置換アリール-2-フェニルエチル-1H-イミダゾール化合物
Document Type and Number:
Japanese Patent JP2011509297
Kind Code:
A
Abstract:
A compound having selective modulating activity at the alpha 2B and/or alpha 2C adrenergic receptor subtypes is represented by the general Formula 1: wherein n=1-4; X is C or N; R1-R6 can be the same or different and are independently selected from the group consisting of H, C1-6 alkyl, OCH3, OH, F, Cl, Br, CH2OH, CH2N(R7)2, C(O)R8, CH2CN, CF3; wherein R7 is H or C1-6 alkyl; and R8 is C1-6 alkyl or aryl. The compounds of Formula 1 can be incorporated in pharmaceutical compositions and used in methods of treatment of alpha 2 receptor mediated diseases and conditions.
Inventors:
Santosh Sea Sinha
Todd M Heidelbo
Sumita S. Bert
Ken Chow
Michael E. Gurst
Todd M Heidelbo
Sumita S. Bert
Ken Chow
Michael E. Gurst
Application Number:
JP2010542297A
Publication Date:
March 24, 2011
Filing Date:
January 05, 2009
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
C07D233/64; A61K31/4174; A61K31/4178; A61P1/04; A61P1/12; A61P3/04; A61P3/10; A61P25/04; A61P25/06; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P27/06; A61P43/00; C07D401/10
Domestic Patent References:
| JPH0770082A | 1995-03-14 |
Foreign References:
| WO2006036507A1 | 2006-04-06 | |||
| WO2002076950A2 | 2002-10-03 | |||
| WO2001000586A1 | 2001-01-04 | |||
| WO2007085556A2 | 2007-08-02 | |||
| EP0390558B1 | 1994-09-07 |
Other References:
JPN6013043622; ＬＡＬＣＨＡＮＤＡＮＩ，Ｓ．Ｇ． ｅｔ ａｌ: Ｂｉｏｃｈｅｍｉｃａｌ Ｐｈａｒｍａｃｏｌｏｇｙ Ｖｏｌ．６７, 2004, ｐ．８７-９６
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki