Title:
ミトコンドリア病の処置のための(ヘテロ)アリール-p-キノン誘導体
Document Type and Number:
Japanese Patent JP2011509298
Kind Code:
A
Abstract:
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
Inventors:
Hinman, Andrew W.
Wesson, Kieron Yi.
Wesson, Kieron Yi.
Application Number:
JP2010542313A
Publication Date:
March 24, 2011
Filing Date:
January 06, 2009
Export Citation:
Assignee:
Edison Pharmaceuticals, Inc.
International Classes:
C07C50/28; A61K31/122; A61P3/00; A61P9/00; A61P21/02; A61P25/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P43/00; C07B57/00
Domestic Patent References:
| JP2009527567A | 2009-07-30 | |||
| JP2008542389A | 2008-11-27 | |||
| JP2009527567A | 2009-07-30 | |||
| JP2008542389A | 2008-11-27 |
Other References:
JPN6013047883; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ ６６（９）, 1944, １５２６-１５３１
JPN6013047884; Ｌｉｐｉｄｓ ２６（１０）, 1991, ８４７-８５２
JPN6013047885; 薬学雑誌 Ｙａｋｕｇａｋｕ Ｚａｓｓｈｉ ９８（４）, 1978, ４３３-４４１
JPN6013047884; Ｌｉｐｉｄｓ ２６（１０）, 1991, ８４７-８５２
JPN6013047885; 薬学雑誌 Ｙａｋｕｇａｋｕ Ｚａｓｓｈｉ ９８（４）, 1978, ４３３-４４１
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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