Title:
新規な方法
Document Type and Number:
Japanese Patent JP2011510097
Kind Code:
A
Abstract:
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
Inventors:
Hook, david
Squirrel, bernard
Kaufman, Daniel
Nap, Matthias
Baptist, Arjard
Poliuks, Philippe
Medlock, Jonathan
Zangotti-Geroza, Antonio
Squirrel, bernard
Kaufman, Daniel
Nap, Matthias
Baptist, Arjard
Poliuks, Philippe
Medlock, Jonathan
Zangotti-Geroza, Antonio
Application Number:
JP2010544498A
Publication Date:
March 31, 2011
Filing Date:
January 16, 2009
Export Citation:
Assignee:
Novartis Age
International Classes:
C07C271/22; C07D207/27; C07D207/38
Domestic Patent References:
| JPH05310664A | 1993-11-22 |
Foreign References:
| WO2008083967A2 | 2008-07-17 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Yasuhito Suzuki