Title:
間充織幹細胞、組成物、及び心臓組織障害の治療方法
Document Type and Number:
Japanese Patent JP2011525355
Kind Code:
A
Abstract:
The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and treatment of inflammatory diseases. The invention also provides methods for using TSG-6 protein that is secreted by MSCs under certain conditions, for repair of cardiac damage and inflammatory disease. The compositions of the invention may be particularly useful in restoring cardiac function following cardiac damage, including, but not limited to, myocardial infarction, as well as in reducing symptoms of inflammatory disease.
Inventors:
Pro Cup, Darwin, Jay.
Lee, Liang, Hwa
Lee, Liang, Hwa
Application Number:
JP2011514618A
Publication Date:
September 22, 2011
Filing Date:
June 18, 2009
Export Citation:
Assignee:
THE TEXAS A&M UNIVERSITY SYSTEM
International Classes:
C12N5/0775; A61K35/28; A61K38/00; A61P9/00; A61P29/00; C12N5/10; C12Q1/68; G01N33/68
Foreign References:
| WO2005033298A1 | 2005-04-14 |
Other References:
J.PHARMACOL.SCI.,2006 MAR,100(3),P.205-10, JPN6014003552, ISSN: 0002734269
AM.J.PHYSIOL.CELL.PHYSIOL.,2008 MAR,294(3),C675-82,EPUB 2008 JAN 30, JPN6014003555, ISSN: 0002734270
BR.J.HAEMATOL.,1990 APR,74(4),P.424-31, JPN6014003559, ISSN: 0002734271
BLOOD,2006 MAR 1,107(5),P.2153-61,EPUB 2005 NOV 8, JPN6014003561, ISSN: 0002734272
PROC.NATL.ACAD.SCI.U.S.A.,2001 JUL 3,98(14),P.7841-5,EPUB 2001 JUN 26, JPN6014003565, ISSN: 0002734273
PLOS ONE,2007 MAY 2,2(5),E416, JPN6014003569, ISSN: 0002734274
FASEB J.,2009 APR,23(MEETING ABSTRACT SUPPLEMENT),297.1, JPN6015000130, ISSN: 0002979333
AM.J.PHYSIOL.CELL.PHYSIOL.,2008 MAR,294(3),C675-82,EPUB 2008 JAN 30, JPN6014003555, ISSN: 0002734270
BR.J.HAEMATOL.,1990 APR,74(4),P.424-31, JPN6014003559, ISSN: 0002734271
BLOOD,2006 MAR 1,107(5),P.2153-61,EPUB 2005 NOV 8, JPN6014003561, ISSN: 0002734272
PROC.NATL.ACAD.SCI.U.S.A.,2001 JUL 3,98(14),P.7841-5,EPUB 2001 JUN 26, JPN6014003565, ISSN: 0002734273
PLOS ONE,2007 MAY 2,2(5),E416, JPN6014003569, ISSN: 0002734274
FASEB J.,2009 APR,23(MEETING ABSTRACT SUPPLEMENT),297.1, JPN6015000130, ISSN: 0002979333
Attorney, Agent or Firm:
Hiroyuki Niwa
Nishio Mira
Nishio Mira