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Title:
効率的で普遍的な多能性幹細胞から神経細胞への分化誘導方法
Document Type and Number:
Japanese Patent JP2012501194
Kind Code:
A
Abstract:
The present invention relates to a method for inducing neural differentiation of stem cells. In more detail, the present invention relates to a method for inducing neural differentiation of stem cells by inhibiting both BMP (bone morphogenetic protein) and Activin/Nodal signaling pathways in the stem cells. The present invention allows all types of stem cells to effectively differentiate into neural precursor cells regardless of conventional methods for stem cell differentiation including floating culture and attachment culture, In addition, since the neural precursor cells induced by the present invention may be differentiated into specific cells ( e . g ., dopaminergic neurons) or oligodendrocytes in higher efficient manner, they may be applied to treatment of incurable nerve diseases ( e.g. , Parkinson's disease or spinal cordinjury) and further provide fundamental data on new drug development.

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Inventors:
Kim Dong-Wook
Kim Tae Sung
Application Number:
JP2011539458A
Publication Date:
January 19, 2012
Filing Date:
August 31, 2010
Export Citation:
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Assignee:
Industry-Academic Corporation Foundation, Yonsei University
International Classes:
C12N5/0735; C12N5/0789; C12N5/0793; A61K35/28; A61K35/30; A61P21/00; A61P25/16; A61P25/28
Domestic Patent References:
JP2008125448A2008-06-05
JP2009534378A2009-09-24
JP2007503811A2007-03-01
Foreign References:
WO2010063848A12010-06-10
WO2009148170A12009-12-10
WO2008056166A22008-05-15
WO2005033298A12005-04-14
WO2009110215A12009-09-11
Other References:
SMITH: "INHIBITION OF ACTIVIN/NODAL SIGNALING PROMOTES SPECIFICATION 以下備考", DEVELOPMENTAL BIOLOGY, vol. V313 N1, JPN5012004545, 11 October 2007 (2007-10-11), US, pages 107 - 117, ISSN: 0002482559
BIOORG MED CHEM LETT. 2008 AUG 1;18(15):4388-92. EPUB 2008 JUN 27., JPN6013012248, ISSN: 0002482560
GENES DEV. 1994 NOV 1;8(21):2602-16., JPN6013012249, ISSN: 0002482561
STEM CELLS. 2007 AUG;25(8):1931-9. EPUB 2007 MAY 3., JPN6013012250, ISSN: 0002482562
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda



 
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