Title:
NPM-ALK、RETおよびBCR-ABLのα-カルボリン阻害剤
Document Type and Number:
Japanese Patent JP2012501984
Kind Code:
A
Abstract:
The present invention relates to compounds of formula (I)
wherein R1, R2 and R3 are as defined in the description,
to their pharmaceutical compositions and use thereof for the treatment of cancer expressing oncogenic ALK protein, particularly anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), inflammatory myofibroblastic tumours (IMT) and non-small cell lung cancer (NSCLC).
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Inventors:
Gamba Corti Passerini, Carlo
Moroni, Luka
Scapozza, Leonardo
Ahmed, Shaheen
Goekjan, Peter G.
Gaylar, David
Popoviks, Florence
Joseph, Benowa
Schneider, Sedlik
Garcia, Pierre
Moroni, Luka
Scapozza, Leonardo
Ahmed, Shaheen
Goekjan, Peter G.
Gaylar, David
Popoviks, Florence
Joseph, Benowa
Schneider, Sedlik
Garcia, Pierre
Application Number:
JP2011525450A
Publication Date:
January 26, 2012
Filing Date:
August 27, 2009
Export Citation:
Assignee:
Universidad' Deli Studio Di Milan-Bicocca
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/496; A61K31/5377; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
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Other References:
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, vol. 43, no. 3, JPN6014009171, 1986, pages 315 - 321, ISSN: 0002758706
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PORTELA-CUBILLO, F., ET AL, J. ORG. CHEM., vol. 73, JPN6015009366, 2008, pages 8124 - 8127, ISSN: 0003023929
STEPHENSON, L., ET AL., JOURNAL OF THE CHEMICAL SOCIETY C, ORGANIC CHEMISTRY, vol. 10, JPN6015009365, 1970, pages 1355 - 1364, ISSN: 0003023930
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Masaaki Ogata
Ishibashi Masayuki
Masaaki Ogata