Title:
抗脂抗体結晶構造を用いた抗体設計
Document Type and Number:
Japanese Patent JP2012511026
Kind Code:
A
Abstract:
The present invention provides crystalline forms of an anti-lipid antibody or fragment thereof, which may further comprise a lipid ligand of said antibody and/or salts, metals, or co-factors. Methods for making such crystals and co-crystals are provided. The lipid may be a bioactive lipid, including sphingolipids such as S1P. X-ray coordinates of such a crystal are provided, as are methods of using this information in antibody design or optimization. Methods for designing a humanized antibody to a lipid are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Antibodies produced by these methods are also provided.
Inventors:
Roger A. Sabadini
Michael Jonathan Wodi Shack
Tom Huxford
Michael Jonathan Wodi Shack
Tom Huxford
Application Number:
JP2011539761A
Publication Date:
May 17, 2012
Filing Date:
December 04, 2009
Export Citation:
Assignee:
Lpath, Inc.
International Classes:
C07K16/18; C07K16/28
Attorney, Agent or Firm:
Masutani Takeshi