Title:
組換えヒトアルファ1-アンチトリプシン
Document Type and Number:
Japanese Patent JP2012524747
Kind Code:
A
Abstract:
The present invention relates recombinant human α1-antitrypsin (rhAAT) comprising N-linked glycans, wherein at least 10% of said N-linked glycans are tetra-antennary glycans; and the degree of capping with sialic acid on said N-linked glycans (Z/A) is at least 50%. The invention further relates to rhAAT for use as a medicament, in particular for use in the prevention and/or treatment of a disease associated with AAT deficiency, and/or a disease involving neutrophil-mediated tissue damage.
Inventors:
Elizabeth Same Blinkman
Cornelis Eric Hack
Ingrid Van den Newwenhof
Cornelis Eric Hack
Ingrid Van den Newwenhof
Application Number:
JP2012506465A
Publication Date:
October 18, 2012
Filing Date:
April 20, 2010
Export Citation:
Assignee:
Krusel Holland Bevey
International Classes:
C07K14/47; C12P21/02; C12N15/09
Domestic Patent References:
| JP2005511051A | 2005-04-28 | |||
| JP2005511051A | 2005-04-28 |
Foreign References:
| WO2008069244A1 | 2008-06-12 | |||
| WO2007102432A1 | 2007-09-13 | |||
| WO2006070011A1 | 2006-07-06 | |||
| WO2008069244A1 | 2008-06-12 | |||
| WO2007102432A1 | 2007-09-13 |
Other References:
JPN6014028548; ＴＲＡＮＳＦＵＳＩＯＮ Ｖｏｌ．４６, 2006, ｐ．１９５９-１９７７
JPN6014028547; Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．１０２, 2003, ｐ．６１-７１
JPN6014028548; ＴＲＡＮＳＦＵＳＩＯＮ Ｖｏｌ．４６, 2006, ｐ．１９５９-１９７７
JPN6014028547; Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．１０２, 2003, ｐ．６１-７１
JPN6014028548; ＴＲＡＮＳＦＵＳＩＯＮ Ｖｏｌ．４６, 2006, ｐ．１９５９-１９７７
Attorney, Agent or Firm:
Kenji Sugimura
Kazuyuki Tomita
Miyuki Ido
Kazuyuki Tomita
Miyuki Ido