Title:
ブルトン型チロシンキナーゼの阻害薬
Document Type and Number:
Japanese Patent JP2012524748
Kind Code:
A
Abstract:
This application discloses 5-phenyl-1H-pyridin-2-one, 6-phenyl-2H-pyridazin-3-one, and 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-II: wherein, variables Q1, Q2, R, X, Y1, Y2, Y2′, Y3, Y4, Y5, m, and p are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-II and at least one carrier, diluent or excipient.
Inventors:
Noord James, Dudeney
Ronald Charles, Holey
Condor, Rama Kay
Rye, Indie
Low, Yen
Ronald Charles, Holey
Condor, Rama Kay
Rye, Indie
Low, Yen
Application Number:
JP2012506475A
Publication Date:
October 18, 2012
Filing Date:
April 21, 2010
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D401/14; A61K31/5377; A61K31/553; A61P19/02; A61P29/00; A61P37/06; A61P43/00; C07D413/14
Domestic Patent References:
| JP2011500752A | 2011-01-06 | |||
| JP2011511027A | 2011-04-07 | |||
| JP2011524404A | 2011-09-01 | |||
| JP2011526279A | 2011-10-06 |
Foreign References:
| WO2006099075A2 | 2006-09-21 | |||
| WO2006021544A1 | 2006-03-02 |
Attorney, Agent or Firm:
Hajime Tsukuni
Satoko Ito
Keiko Ozawa
Satoko Ito
Keiko Ozawa