Title:
IGF-Iタンパク質、緩衝化剤および等張化剤を含む薬学的組成物
Document Type and Number:
Japanese Patent JP2013514340
Kind Code:
A
Abstract:
The present invention relates to a pharmaceutical composition, comprising an Insulin-like growth factor I (IGF-I) protein as active pharmaceutical ingredient (API), a tonicity agent and a buffer. This composition may be administered as injection or infusion and is especially useful for the treatment, prevention and/or delay of progression of neurodegenerative disorders, in particular Alzheimer's Disease (AD), a motor neuron disease (MND), in particular amyotrophic lateral sclerosis (ALS) or Spinal Muscular Atrophy (SMA) or a Muscular Dystrophy (MD), in particular Duchenne Muscular Dystrophy (DMD) or Myotonic Dystrophy (MMD).
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Inventors:
Mahler, Hans-Christian
Pappenberger, Astrid
Pappenberger, Astrid
Application Number:
JP2012543809A
Publication Date:
April 25, 2013
Filing Date:
December 20, 2010
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K38/27; A61K9/08; A61K9/19; A61K47/12; A61K47/18; A61K47/20; A61K47/22; A61K47/26; A61K47/34; A61K47/48; A61P21/02; A61P25/28
Domestic Patent References:
| JP2002541212A | 2002-12-03 | |||
| JP2002516871A | 2002-06-11 | |||
| JP2001522813A | 2001-11-20 | |||
| JPH05507278A | 1993-10-21 | |||
| JPH08505617A | 1996-06-18 | |||
| JP2009521482A | 2009-06-04 |
Foreign References:
| WO1999055362A1 | 1999-11-04 | |||
| WO2008025528A1 | 2008-03-06 | |||
| WO2009121759A2 | 2009-10-08 |
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Suzuki Otoya
St. Tanaka
Yuichi Okazaki
Takaaki Goto
Toshio Miyake
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Suzuki Otoya
St. Tanaka
Yuichi Okazaki
Takaaki Goto
Toshio Miyake