Title:
ヒト胚性幹細胞の分化
Document Type and Number:
Japanese Patent JP2013526279
Kind Code:
A
Abstract:
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.
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Inventors:
Shoe, jean
Application Number:
JP2013510273A
Publication Date:
June 24, 2013
Filing Date:
May 11, 2011
Export Citation:
Assignee:
Janssen Biotech, Inc.
International Classes:
C12N5/0735
Domestic Patent References:
| JP2008212150A | 2008-09-18 |
Foreign References:
| US20090263896A1 | 2009-10-22 | |||
| WO2009132083A2 | 2009-10-29 | |||
| US20090170198A1 | 2009-07-02 |
Other References:
JPN6015017739; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ （２００６） Ｖｏｌ．２４， Ｎｏ．１１， ｐ．１３９２-１４０１
JPN6015017736; Ｎａｔｕｒｅ Ｃｈｅｍｉｃａｌ Ｂｉｏｌｏｇｙ （２００９） Ｖｏｌ．５， Ｎｏ．４， ｐｐ．２５８-２６５
JPN6015017737; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ （２００８） Ｖｏｌ．２６， Ｎｏ．４， ｐｐ．４４３-４５２
JPN6015017739; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ （２００６） Ｖｏｌ．２４， Ｎｏ．１１， ｐ．１３９２-１４０１
JPN6015017736; Ｎａｔｕｒｅ Ｃｈｅｍｉｃａｌ Ｂｉｏｌｏｇｙ （２００９） Ｖｏｌ．５， Ｎｏ．４， ｐｐ．２５８-２６５
JPN6015017737; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ （２００８） Ｖｏｌ．２６， Ｎｏ．４， ｐｐ．４４３-４５２
JPN6015017739; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ （２００６） Ｖｏｌ．２４， Ｎｏ．１１， ｐ．１３９２-１４０１
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Yasuhito Suzuki
Junko Kobayashi
Norio Omori
Yasuhito Suzuki