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Title:
CCR2のシクロヘキシル-アゼチジニルアンタゴニスト
Document Type and Number:
Japanese Patent JP2013533233
Kind Code:
A
Abstract:
The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

Inventors:
Chan, Souk Inn
Sui, Chihua
Lanter, James, Sea.
Application Number:
JP2013514354A
Publication Date:
August 22, 2013
Filing Date:
June 09, 2011
Export Citation:
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Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D401/14; A61K31/416; A61K31/4178; A61K31/422; A61K31/423; A61K31/427; A61K31/437; A61K31/4439; A61K31/451; A61K31/695; A61P1/02; A61P1/04; A61P3/00; A61P3/04; A61P3/10; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P27/12; A61P29/00; A61P31/04; A61P31/06; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07D403/12; C07D403/14; C07D405/14; C07D413/12; C07D413/14; C07D417/14; C07D471/04; C07F7/18
Domestic Patent References:
JP2012524110A2012-10-11
JP2012524107A2012-10-11
JP2012524111A2012-10-11
JP2012511582A2012-05-24
JP2006516145A2006-06-22
JP2002505684A2002-02-19
JP2003513970A2003-04-15
JP2012524110A2012-10-11
JP2012524107A2012-10-11
JP2012524111A2012-10-11
JP2012511582A2012-05-24
JP2006516145A2006-06-22
JP2002505684A2002-02-19
JP2003513970A2003-04-15
Foreign References:
WO2007053498A12007-05-10
WO2007053498A12007-05-10
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Yasuhito Suzuki



 
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