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Title:
薬物送達系の構成成分の一時的コンジュゲーションのための調整可能な生分解性リンカー分子、及びそれを用いて調製される薬物送達系
Document Type and Number:
Japanese Patent JP2013537224
Kind Code:
A
Abstract:
The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.

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Inventors:
Christiane Johanna Ferdinand Reiken
Johannes Ana Wilhelms Kleitzer
Cornelis Franciscus van Nostrum
Stephen van der Wal
Wilhelms Evelhardus Heninck
Robertus Matthias Joseph Riskamp
Isyl Altintas
Application Number:
JP2013529089A
Publication Date:
September 30, 2013
Filing Date:
July 14, 2011
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Crystal delivery bee buoy
International Classes:
A61K47/48; A61K31/337; A61K31/573; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
JPH0680624A1994-03-22
JPH0680624A1994-03-22
Foreign References:
WO2010033022A12010-03-25
WO2010010324A12010-01-28
WO2010033022A12010-03-25
WO2010010324A12010-01-28
Other References:
JPN5013010477; ＣＵＲＣＩ　ＭＩＣＨＥＬＥ: 'ＳＹＮＴＨＥＳＩＳ　ＯＦ　ＦＵＮＣＴＩＯＮＡＬＩＺＥＤ　ＡＣＲＹＬＡＴＥＳ' ＯＲＧＡＮＩＣ　ＰＲＥＰＡＲＡＴＩＯＮＳ　ＡＮＤ　ＰＲＯＣＥＤＵＲＥＳ　ＩＮＴＥＲＮＡＴＩＯＮＡＬ Ｖ２５　Ｎ６, 19930101, Ｐ６４９-６５７, ＯＲＧＡＮＩＣ　ＰＲＥＰＡＲＡＴＩＯＮＳ　ＡＮＤ　ＰＲＯＣＥＤＵＲＥＳ　ＣＯ．
JPN5013010477; ＣＵＲＣＩ　ＭＩＣＨＥＬＥ: 'ＳＹＮＴＨＥＳＩＳ　ＯＦ　ＦＵＮＣＴＩＯＮＡＬＩＺＥＤ　ＡＣＲＹＬＡＴＥＳ' ＯＲＧＡＮＩＣ　ＰＲＥＰＡＲＡＴＩＯＮＳ　ＡＮＤ　ＰＲＯＣＥＤＵＲＥＳ　ＩＮＴＥＲＮＡＴＩＯＮＡＬ Ｖ２５　Ｎ６, 19930101, Ｐ６４９-６５７, ＯＲＧＡＮＩＣ　ＰＲＥＰＡＲＡＴＩＯＮＳ　ＡＮＤ　ＰＲＯＣＥＤＵＲＥＳ　ＣＯ．
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro



 
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