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Title:
変異CFTRタンパク質の修飾因子としての化合物及びCFTRタンパク質異常に関連する病気の治療へのその使用
Document Type and Number:
Japanese Patent JP2013537225
Kind Code:
A
Abstract:
The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ”F508-CFTR, or another mutation of class II.

Inventors:
Odorcek, Norbert
The Ellen Cavich, Piotr
Vie Torrek, Gregosh
Edelman, alexander
Tonderie, Daniel
Flitch, janine
Application Number:
JP2013529094A
Publication Date:
September 30, 2013
Filing Date:
June 20, 2011
Export Citation:
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Assignee:
Institut Bio High My Office Bipan
International Classes:
A61K31/663; A61K31/194; A61K31/496; A61K31/52; A61P1/18; A61P43/00; C07D219/00; C07D473/22
Domestic Patent References:
JP2008504291A2008-02-14
JP2008504291A2008-02-14
Foreign References:
WO2010059215A12010-05-27
WO2010059215A12010-05-27
US3770514A1973-11-06
Other References:
JPN5013010355; ＳＯＭＭＥＲ　Ｖ　Ｋ: 'ＺＵＲ　ＳＰＡＬＴＵＮＧ　ＴＥＲＴＩＡＥＲＥＲ　ＰＨＯＳＰＨＩＮＥ' ＺＥＩＴＳＣＨＲＩＦＴ　ＦＵＲ　ＡＮＯＲＧＡＮＩＳＣＨＥ　ＵＮＤ　ＡＬＬＧＥＭＥＩＮＥ　ＣＨＥＭＩＥ Ｖ３７６　Ｎ３７, 19700101, Ｐ３７-４３, ＷＩＬＥＹ-ＶＣＨ　ＶＥＲＬＡＧ　ＧＭＢＨ　＆　ＣＯ
JPN5013010354; ＭＡＳＴＡＬＥＲＺ: ＲＯＣＺＮＩＫＩ　ＣＨＥＭＩＩ Ｖ３９, 1965, Ｐ１１２９-１１３０, ＥＬＳＥＶＩＥＲ
JPN6015011509; Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒｇａｎｉｃ　Ｃｈｅｍｉｓｔｒｙ，　１９８４，　Ｖｏｌ．４９（２６），　ｐ５１３２-５１３６
JPN6015011510; Ｒｕｓｓｉａｎ　Ｃｈｅｍｉｃａｌ　Ｂｕｌｌｅｔｉｎ，　２００４，　Ｖｏｌ．５３（９），　ｐ．２０００-２００７
Attorney, Agent or Firm:
Ippei Watanabe
Koji Kikawa
Hiroyuki Sato
Shigeru Koike



 
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