Title:
抗ＡＮＧＰＴＬ３抗体及びその使用
Document Type and Number:
Japanese Patent JP2014523739
Kind Code:
A
Abstract:
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hANGPTL3) is provided. The human anti-hANGPTL3 antibodies are useful in treating diseases or disorders associated with ANGPTL3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth. Furthermore, the anti-hANGPTL3 antibodies can be administered to a subject in need thereof to prevent or treat diseases or disorders, for which abnormal lipid metabolism is a risk factor. Such diseases or disorders include cardiovascular diseases, such as atherosclerosis and coronary artery diseases; acute pancreatitis; nonalcoholic steatohepatitis (NASH); diabetes; obesity; and the like.
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Inventors:
Mark double Sleeman
Victoria グサロヴァ
Andrew Jay Murphy
Victoria グサロヴァ
Andrew Jay Murphy
Application Number:
JP2014515976A
Publication Date:
September 18, 2014
Filing Date:
June 14, 2012
Export Citation:
Assignee:
リジェネロン Pharmaceuticals, Incorporated REGENERON PHARMACEUTICALS, INC.
International Classes:
C12N15/09; A61K31/455; A61K39/395; A61K45/00; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P43/00; C07K16/26; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/08
Domestic Patent References:
| JP2010512320A | 2010-04-22 | |||
| JP2010505418A | 2010-02-25 |
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LEE, E-C. ET AL., J. BIOL. CHEM., vol. 284, JPN6016011810, 2009, pages 13735 - 13745, ISSN: 0003286665
SONNENBURG, W.K. ET AL., J. LIPID RES., vol. 50, JPN6016011813, 2009, pages 2421 - 2429, ISSN: 0003286666
BROXMEYER, H.E. ET AL., BLOOD CELL. MOL. DIS., vol. 48, JPN6016011815, 7 October 2011 (2011-10-07), pages 25 - 29, ISSN: 0003286667
ONO, M. ET AL., J. BIOL. CHEM., vol. 278, no. 43, JPN6016011818, 2003, pages 41804 - 41809, ISSN: 0003286668
LABRIJN, A.F. ET AL., NAT. BIOTECHNOL., vol. 27, no. 8, JPN6016011819, 2009, pages 767 - 771, ISSN: 0003286669
GUSAROVA, V. ET AL., J. LIPID RES., vol. 56, JPN6016011822, 2015, pages 1308 - 1317, ISSN: 0003286670
LEE, E-C. ET AL., J. BIOL. CHEM., vol. Vol.284, No.20, pp.13735-13745, JPN6017025771, 2009, pages 1 - 14, ISSN: 0003597145
KARLSSON, R. AND LARSSON, A., METHODS MOL. BIOL., vol. 248, JPN6017025776, 2004, pages 389 - 415, ISSN: 0003597146
KATSAMBA, P.S. ET AL., ANAL. BIOCHEM., vol. 352, JPN6017025763, 2006, pages 208 - 221, ISSN: 0003597140
秋山徹 監修, バイオ実験に絶対使える統計の基本Q＆A, vol. 第2刷, JPN6017025765, 5 February 2013 (2013-02-05), pages 44 - 45, ISSN: 0003597141
LEE, E-C. ET AL., J. BIOL. CHEM., vol. 284, no. 20, JPN6017025769, 2009, pages 1 - 14, ISSN: 0003597144
Attorney, Agent or Firm:
Junji Yuita
Noriyuki Takebayashi
Noriyuki Takebayashi