Title:
改変ＡＣＥ２ポリペプチド
Document Type and Number:
Japanese Patent JP2016504042
Kind Code:
A
Abstract:
本発明は改変アンジオテンシン変換酵素2（ACE2）ポリペプチドならびにその医薬および分析用途に関する。特に、本発明はZn2+枯渇、Zn2+非含有、混合金属および金属イオン置換ACE2、ならびにこれらの変異体の製造方法およびその用途、例えば、これらのACE2変異体の治療および分析用途に関する。【選択図】 なし
Inventors:
Reusner, Hans
Pebar, Bernhard
Schuster, Manfred
Strunner, Stephan
Pebar, Bernhard
Schuster, Manfred
Strunner, Stephan
Application Number:
JP2015552067A
Publication Date:
February 12, 2016
Filing Date:
January 13, 2014
Export Citation:
Assignee:
Apeiron Biologics AG
International Classes:
C12N9/64; A61K38/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/16; A61P13/12; A61P43/00; C12P21/02
Domestic Patent References:
| JP2011519264A | 2011-07-07 | |||
| JP2011516501A | 2011-05-26 |
Other References:
TIPNIS, SARAH R. ET AL.: "A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-", J. BIOL. CHEM., vol. Vol. 275, JPN6017040722, 2000, pages pp. 33238-33243
BUNNING, PETER ET AL.: "The functional role of zinc in angiotensin converting enzyme: implications for the enzyme mechanism", J. INORG. BIOCHEM., vol. Vol. 24, JPN6017040726, 1985, pages pp. 183-198
BUNNING, PETER ET AL.: "The functional role of zinc in angiotensin converting enzyme: implications for the enzyme mechanism", J. INORG. BIOCHEM., vol. Vol. 24, JPN6017040726, 1985, pages pp. 183-198
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Takashima Ejima
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Takashima Ejima