Title:
VARIANTS OF TNFSF15 AND DCR3 ASSOCIATED WITH CROHN'S DISEASE
Document Type and Number:
Japanese Patent JP2018148931
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide variants of TNFSF15 and DCR3 associated with Crohn's disease.SOLUTION: Described herein are a method and a composition related to the discovery of associations in TNFSF15 15 and DcR3 genetic loci across in Caucasian, Puerto Rican, and Korean Crohn's Disease, as demonstrated via trans-ethnic fine mapping. The present invention provides a method of quantifying risk and diagnosing susceptibility to Crohn's disease in a subject by determining the presence of one or more risk variants are at the TNFSF15 (or TL1A) and/or DcR3 genetic loci.SELECTED DRAWING: Figure 4
Inventors:
DERMOT P MCGOVERN
Application Number:
JP2018124311A
Publication Date:
September 27, 2018
Filing Date:
June 29, 2018
Export Citation:
Assignee:
CEDARS SINAI MEDICAL CENTER
International Classes:
C12Q1/6883; A61K45/00; A61P1/04; A61P37/06; A61P43/00; C07K14/525
Foreign References:
| US20110045476A1 | 2011-02-24 | |||
| WO2009105590A2 | 2009-08-27 | |||
| WO2008106451A2 | 2008-09-04 |
Other References:
ATSUSHI HIRANO, ET AL.: "Association Study of 71 European Crohn's Disease Susceptibility Loci in a Japanese Population", INFLAMMATORY BOWEL DISEASES, vol. 19, JPN6018011987, 1 March 2013 (2013-03-01), pages 526 - 533, XP055310610, ISSN: 0004205819, DOI: 10.1097/MIB.0b013e31828075e7
CAMILLE JUNG, ET AL.: "Genotype/Phenotype Analyses for 53 Crohn's Disease Associated Genetic Polymorphisms", PLOS ONE, vol. 7, JPN6018011989, 2012, pages 1 - 10, ISSN: 0004205820
GASTROENTEROLOGY,MAY 2013,VOL.144,NO.5,P.S466 (AVAILABLE ONLINE ON APR.27 2013), JPN6020029969, ISSN: 0004325729
DBSNP SHORT GENETIC VARIATIONS, SUBMITTED SNP(SS) DETAILS: SS566368983, NCBI, UPLOADED ON 2012.11.22, JPN6020029970, ISSN: 0004325730
CAMILLE JUNG, ET AL.: "Genotype/Phenotype Analyses for 53 Crohn's Disease Associated Genetic Polymorphisms", PLOS ONE, vol. 7, JPN6018011989, 2012, pages 1 - 10, ISSN: 0004205820
GASTROENTEROLOGY,MAY 2013,VOL.144,NO.5,P.S466 (AVAILABLE ONLINE ON APR.27 2013), JPN6020029969, ISSN: 0004325729
DBSNP SHORT GENETIC VARIATIONS, SUBMITTED SNP(SS) DETAILS: SS566368983, NCBI, UPLOADED ON 2012.11.22, JPN6020029970, ISSN: 0004325730
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita