Title:
ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN
Document Type and Number:
Japanese Patent JP2018150378
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide pharmaceutical compositions comprising as an active ingredient an antigen-binding molecule that induces an immune response in subjects affected with cancer or infected with foreign biological species when administered to these subjects.SOLUTION: A pharmaceutical composition induces an immune response to an antigen, which comprises as an active ingredient an antigen-binding molecule, wherein the antigen-binding molecule comprises an antigen-binding domain whose binding activity to the antigen changes depending on an ion concentration condition and comprises an FcRn-binding domain having binding activity to FcRn in a neutral pH range.SELECTED DRAWING: None
Inventors:
IGAWA TOMOYUKI
MAEDA ATSUHIKO
HARATANI KENTA
TACHIBANA TATSUHIKO
MAEDA ATSUHIKO
HARATANI KENTA
TACHIBANA TATSUHIKO
Application Number:
JP2018109098A
Publication Date:
September 27, 2018
Filing Date:
June 07, 2018
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
A61K39/395; A61P35/00; A61P43/00
Foreign References:
| WO2009125825A1 | 2009-10-15 | |||
| WO2010058860A1 | 2010-05-27 |
Other References:
YEUNG,Y.A. ET AL.: "Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pha", J. IMMUNOL., vol. 182, no. 12, JPN6016022970, 15 June 2009 (2009-06-15), pages 7663 - 7671, ISSN: 0004320654
MI,W. ET AL.: "Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments.", J. IMMUNOL., vol. 181, no. 11, JPN6016022973, 1 December 2008 (2008-12-01), pages 7550 - 7561, XP002597457, ISSN: 0004320655
IGAWA,T. ET AL.: "Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutr", NAT. BIOTECHNOL., vol. 28, no. 11, JPN6016022967, November 2010 (2010-11-01), pages 1203 - 1207, XP009153598, ISSN: 0004320656, DOI: 10.1038/nbt.1691
MI,W. ET AL.: "Targeting the neonatal fc receptor for antigen delivery using engineered fc fragments.", J. IMMUNOL., vol. 181, no. 11, JPN6016022973, 1 December 2008 (2008-12-01), pages 7550 - 7561, XP002597457, ISSN: 0004320655
IGAWA,T. ET AL.: "Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutr", NAT. BIOTECHNOL., vol. 28, no. 11, JPN6016022967, November 2010 (2010-11-01), pages 1203 - 1207, XP009153598, ISSN: 0004320656, DOI: 10.1038/nbt.1691
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto