Title:
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF
Document Type and Number:
Japanese Patent JP2018150379
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of ATR protein kinase and combination therapies thereof.SOLUTION: According to the present invention, there are provided compounds useful as inhibitors of ATR protein kinase and combination therapies. There are also provided pharmaceutically acceptable compositions comprising the compounds of the invention; methods of treating of various diseases, disorders, and conditions using the compounds of the invention; processes for preparing the compounds of the invention; intermediates for the preparation of the compounds of the invention; and methods of using the compounds in in-vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of the invention have formula I: In the formula, the variables are as defined herein.SELECTED DRAWING: None
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Inventors:
JOHN ROBERT POLLARD
PHILIP MICHAEL REAPER
MOHAMMED ASMAL
PHILIP MICHAEL REAPER
MOHAMMED ASMAL
Application Number:
JP2018110161A
Publication Date:
September 27, 2018
Filing Date:
June 08, 2018
Export Citation:
Assignee:
VERTEX PHARMA
International Classes:
A61K31/4965; A61K31/282; A61K31/4184; A61K31/4188; A61K31/497; A61K31/7048; A61K31/7068; A61K33/243; A61K41/00; A61K45/00; A61K45/06; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita