Title:
METHOD OF USING NON-RARE CELLS TO DETECT RARE CELLS
Document Type and Number:
Japanese Patent JP2018185339
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide seminal computational approaches for utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs).SOLUTION: A method comprises; a) providing a sample suspected of having at least one rare cell and at least one cell that is present at a concentration that is at least 10 times that of the rare cell; b) bringing the sample into contact with at least one detectable agent; c) performing a cell imaging process on the sample of the step (b) to generate a cell image; and d) detecting the at least one rare cell in comparison with other cells in the sample by analyzing the cells from the image of the step (c), thereby detecting the rare cell in the sample.SELECTED DRAWING: Figure 3
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Inventors:
PETER KUHN
ANAND KOLATKAR
JOSHUA KUNKEN
DENA MARRINUCCI
YANG XING
JOHN R STUELPNAGEL
ANAND KOLATKAR
JOSHUA KUNKEN
DENA MARRINUCCI
YANG XING
JOHN R STUELPNAGEL
Application Number:
JP2018145154A
Publication Date:
November 22, 2018
Filing Date:
August 01, 2018
Export Citation:
Assignee:
SCRIPPS RESEARCH INST
EPIC SCIENCES INC
EPIC SCIENCES INC
International Classes:
G01N33/574; C12Q1/04
Domestic Patent References:
| JP2009525468A | 2009-07-09 |
Other References:
STINE-KATHREIN KRAEFT ET AL.: "Detection and Analysis of Cancer Cells in Blood and Bone Marrow Using a Rare Event Imaging System", CLIN. CANCER RES., vol. 6, JPN7014002253, February 2000 (2000-02-01), pages 434 - 442, XP055141215, ISSN: 0004297964
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto